2711006-66-3
Chemical Structure
ZXH-4-130
- CAS No.: 2711006-66-3
- Formula:C46H58N6O9S
- Molecular Weight:871.05
IUPAC Name: (2S,4R)-1-((2S)-2-(11-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)undecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChIKey: CZQHTMJBCZCOMW-ZALOBHIXSA-N
SMILES: O=C([C@H]1N(C([C@@H](NC(CCCCCCCCCCOC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
Biological Activity: ZXH-4-130 is a potent and selective Cereblon (CRBN) degrader. ZXH-4-130 recruits the VHL E3 ligase to specifically target CRBN as a substrate for selective degradation as a hetero-PROTAC molecule. ZXH-4-130 can be applied in studies on the biological functions of CRBN and related research of frontotemporal dementia[1][2].
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ZXH-4-130 | 99.70% | ZXH-4-130 is a potent and selective Cereblon (CRBN) degrader. ZXH-4-130 recruits the VHL E3 ligase to specifically target CRBN as a substrate for selective degradation as a hetero-PROTAC molecule. ZXH-4-130 can be applied in studies on the biological functions of CRBN and related research of frontotemporal dementia. | ||||||||||||||||||||
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References
- [1]. Powell CE, et al. Selective degradation-inducing probes for studying cereblon (CRBN) biology. RSC medicinal chemistry. 2021 Aug 18;12(8):1381-1390. [Content Brief]
- [2]. Lam M, et al. Cholesterol Dysregulation Drives Seed-Dependent Tau Aggregation in Patient Stem Cell-Derived Models of Tauopathy. bioRxiv [Preprint]. 2023 Dec 12:2023.12.11.571147. [Content Brief]
