2724919-70-2
Chemical Structure
KB05-Biotin
- No. CAS: 2724919-70-2
- Formula:C42H57BrN8O8S
- Molecular Weight:913.92
InChIKey: VIVVJJVDQXSBEL-HKGQQODZSA-N
SMILES: O=C(NCCOCCOCCOCCOCCN1N=NC(CCCCNC(C2=CC=C(N(C(C=C)=O)C3=CC=C(Br)C=C3)C=C2)=O)=C1)CCCC[C@H]4[C@]5([H])[C@](NC(N5)=O)([H])CS4
Biological Activity: KB05-Biotin is streptavidin-conjugated KB05 (HY-149461) that retains the site-specific cysteine covalent reactivity of KB05, enabling specific detection of target proteins via the biotin-streptavidin system. KB05-Biotin serves as a site-specific probe in ELISA-ABPP assays for screening electrophilic small molecules that bind to scout fragment-sensitive cysteines on target proteins in cell lysates, without the need for protein purification[1].
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KB05-Biotin | KB05-Biotin is streptavidin-conjugated KB05 (HY-149461) that retains the site-specific cysteine covalent reactivity of KB05, enabling specific detection of target proteins via the biotin-streptavidin system. KB05-Biotin serves as a site-specific probe in ELISA-ABPP assays for screening electrophilic small molecules that bind to scout fragment-sensitive cysteines on target proteins in cell lysates, without the need for protein purification. | |||||||||||||||||||||
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