27314-13-2
Chemical Structure
Norflurazon
Synonym(s): SAN 9789
- CAS No.: 27314-13-2
- Formula:C12H9ClF3N3O
- Molecular Weight:303.67
IUPAC Name: 4-chloro-5-(methylamino)-2-(3-(trifluoromethyl)phenyl)pyridazin-3(2H)-one
InChIKey: NVGOPFQZYCNLDU-UHFFFAOYSA-N
SMILES: O=C1C(Cl)=C(C=NN1C2=CC=CC(C(F)(F)F)=C2)NC
Biological Activity: Norflurazon (SAN 9789) is a pre-emergence Herbicide. Norflurazon non-competitively inhibits phytoene desaturase by competing with the enzyme cofactor and disrupts carotenoid biosynthesis, thereby leading to chlorophyll photodegradation and chlorosis. Norflurazon inhibits MGDG synthase, CDP-choline phosphotransferase, Omega-3 FAD7 desaturase, and PG delta-3-trans desaturase, and activates LysoPC-acyltransferase and Omega-3 FAD3 desaturase. Norflurazon inhibits photosynthetic membrane organization, mitochondrial respiration, ATP production, PI3K signaling, and ERK1/2 phosphorylation. Norflurazon activates MAPK P38 phosphorylation and ER stress signaling. Norflurazon induces morphological malformations and cardiovascular effects in zebrafish embryos[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Norflurazon | 99.94% | Norflurazon (SAN 9789) is a pre-emergence Herbicide. Norflurazon non-competitively inhibits phytoene desaturase by competing with the enzyme cofactor and disrupts carotenoid biosynthesis, thereby leading to chlorophyll photodegradation and chlorosis. Norflurazon inhibits MGDG synthase, CDP-choline phosphotransferase, Omega-3 FAD7 desaturase, and PG delta-3-trans desaturase, and activates LysoPC-acyltransferase and Omega-3 FAD3 desaturase. Norflurazon inhibits photosynthetic membrane organization, mitochondrial respiration, ATP production, PI3K signaling, and ERK1/2 phosphorylation. Norflurazon activates MAPK P38 phosphorylation and ER stress signaling. Norflurazon induces morphological malformations and cardiovascular effects in zebrafish embryos. | ||||||||||||||||||||
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Norflurazon (Standard) | ≥98% | Norflurazon (Standard) (SAN 9789 (Standard)) is the analytical standard of Norflurazon (HY-114849). This product is intended for research and analytical applications. Norflurazon (SAN 9789) is a pre-emergence Herbicide. Norflurazon non-competitively inhibits phytoene desaturase by competing with the enzyme cofactor and disrupts carotenoid biosynthesis, thereby leading to chlorophyll photodegradation and chlorosis. Norflurazon inhibits MGDG synthase, CDP-choline phosphotransferase, Omega-3 FAD7 desaturase, and PG delta-3-trans desaturase, and activates LysoPC-acyltransferase and Omega-3 FAD3 desaturase. Norflurazon inhibits photosynthetic membrane organization, mitochondrial respiration, ATP production, PI3K signaling, and ERK1/2 phosphorylation. Norflurazon activates MAPK P38 phosphorylation and ER stress signaling. Norflurazon induces morphological malformations and cardiovascular effects in zebrafish embryos. | ||||||||||||||||||||
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Norflurazon-13C,d3 | Norflurazon-13C,d3 (SAN 9789-13C,d3) is the d3, 13C-labeled Norflurazon (HY-114849). Norflurazon (SAN 9789) is a pre-emergence Herbicide. Norflurazon non-competitively inhibits phytoene desaturase by competing with the enzyme cofactor and disrupts carotenoid biosynthesis, thereby leading to chlorophyll photodegradation and chlorosis. Norflurazon inhibits MGDG synthase, CDP-choline phosphotransferase, Omega-3 FAD7 desaturase, and PG delta-3-trans desaturase, and activates LysoPC-acyltransferase and Omega-3 FAD3 desaturase. Norflurazon inhibits photosynthetic membrane organization, mitochondrial respiration, ATP production, PI3K signaling, and ERK1/2 phosphorylation. Norflurazon activates MAPK P38 phosphorylation and ER stress signaling. Norflurazon induces morphological malformations and cardiovascular effects in zebrafish embryos. | |||||||||||||||||||||
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References
- [1]. Abrous-Belbachir O, et al. Evidence that norflurazon affects chloroplast lipid unsaturation in soybean leaves (Glycine max L.). Journal of agricultural and food chemistry. 2009 Dec 09;57(23):11434-40. [Content Brief]
- [2]. Leetanasaksakul K, et al. Proteomic analysis of differential responses to norflurazon herbicide in the model green alga Chlamydomonas reinhardtii. Scientific reports. 2025 Aug 27;15(1):31601.
- [3]. Niemann L, et al. First draft prepared by Lars Niemann1 and Alan Boobis2 Department of Pesticides Safety, German Federal Institute for Risk Assessment, Berlin, Germany 2 Department of Medicine, Imperial College London, London, United Kingdom[J].
- [4]. Hong T, et al. Norflurazon causes cell death and inhibits implantation-related genes in porcine trophectoderm and uterine luminal epithelial cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024 Apr;186:114559.
- [5]. An G, et al. Norflurazon causes developmental defects including cardiovascular abnormalities in early-stage zebrafish (Danio rerio)[J]. Journal of Animal Reproduction and Biotechnology, 2022, 37(3): 176-182.
