2735720-80-4
2735720-80-4
Chemical Structure
SRX3212
- CAS No.: 2735720-80-4
- Formula:C26H23N3O6S
- Molecular Weight:505.54
InChIKey: ZMMQGCYUYDMFPB-UHFFFAOYSA-N
SMILES: O=C1C=C(N2CCOCC2)OC3=C1SC=C3C4=CC(C(NCC5=CC=CN=C5)=O)=C6OCCOC6=C4
Biological Activity: SRX3212 is a potent PI3Kα/BRD4 inhibitor with human IC50 values of 22 nM, 3.7 nM, and 32 nM for PI3Kα, BRD4BD1, and BRD4BD2, respectively. SRX3212 inhibits PI3K kinase activity and blocks acetyllysine binding function of BRD4BD1 and BRD4BD2. SRX3212 can be used for the research of mantle cell lymphoma, colon carcinoma, neuroblastoma, prostate cancer[1].
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SRX3212 | SRX3212 is a potent PI3Kα/BRD4 inhibitor with human IC50 values of 22 nM, 3.7 nM, and 32 nM for PI3Kα, BRD4BD1, and BRD4BD2, respectively. SRX3212 inhibits PI3K kinase activity and blocks acetyllysine binding function of BRD4BD1 and BRD4BD2. SRX3212 can be used for the research of mantle cell lymphoma, colon carcinoma, neuroblastoma, prostate cancer. | |||||||||||||||||||||
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Keywords
