2765180-17-2
Chemical Structure
P62-RNF168 agonist-1
- CAS No.: 2765180-17-2
- Formula:C19H19N7O3
- Molecular Weight:393.40
IUPAC Name: 6-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-4-yl)quinazoline-2,4-diamine
InChIKey: SWULRQWLALOGFO-UHFFFAOYSA-N
SMILES: NC1=C2C(C=CC(C3=CN(C4=CC(OC)=C(C(OC)=C4)OC)N=N3)=C2)=NC(N)=N1
Biological Activity: P62-RNF168 agonist-1 (compound 5a) is a low cytotoxicity P62-RNF168 agonist that enhances the interaction between P62 and RNF168. P62-RNF168 agonist-1 induces a reduction in H2A ubiquitination mediated by RNF168 and impairs homologous recombination-mediated DNA repair. P62-RNF168 agonist-1 also inhibits the growth of xenograft tumors in mice in a dose-dependent manner[1].
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P62-RNF168 agonist-1 | 98.03% | P62-RNF168 agonist-1 (compound 5a) is a low cytotoxicity P62-RNF168 agonist that enhances the interaction between P62 and RNF168. P62-RNF168 agonist-1 induces a reduction in H2A ubiquitination mediated by RNF168 and impairs homologous recombination-mediated DNA repair. P62-RNF168 agonist-1 also inhibits the growth of xenograft tumors in mice in a dose-dependent manner. | ||||||||||||||||||||
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