2766450-03-5
2766450-03-5
Chemical Structure
Mc-Pro-PAB-MMAE
- CAS No.: 2766450-03-5
- Formula:C64H95N9O14
- Molecular Weight:1214.49
InChIKey: UFQZXPPWLSVBMB-IGULLWJISA-N
SMILES: O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H]4N(CCC4)C(CNC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O
Biological Activity: Mc-Pro-PAB-MMAE is a Drug-Linker Conjugate for ADC. Mc-Pro-PAB-MMAE consists of Monomethyl auristatin E (HY-15162) and a linker. Mc-Pro-PAB-MMAE can be used for synthesis of ADCs[1][2].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Mc-Pro-PAB-MMAE | 99.16% | Mc-Pro-PAB-MMAE is a Drug-Linker Conjugate for ADC. Mc-Pro-PAB-MMAE consists of Monomethyl auristatin E (HY-15162) and a linker. Mc-Pro-PAB-MMAE can be used for synthesis of ADCs. | ||||||||||||||||||||
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References
- [1]. Ilaria BIANCOFIORE, et al. Fibroblast activation protein ligands for targeted delivery applications. Patent, WO2021160825, 2021-08-19.
- [2]. Bocci M, et al. In vivo activation of FAP-cleavable small molecule-drug conjugates for the targeted delivery of camptothecins and tubulin poisons to the tumor microenvironment[J]. Journal of Controlled Release, 2024, 367: 779-790. [Content Brief]
Keywords
