2766510-90-9
Chemical Structure
PSMA-SulfoCy7
- CAS No.: 2766510-90-9
- Formula:C90H112ClN13O20S2
- Molecular Weight:1795.51
InChIKey: RUKQDBVJHBLZJI-RNANNXKZSA-N
SMILES: O=C([C@@H](NC([C@@H](NC(CCC(NCCCCCC(N(CC1=CC(Cl)=CC=C1)CCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)CC3=CC=C(C=C3)O)NCCCN(N=N4)C=C4CNC(CCCCC[N+](C5=CC=C(C=C5C6(C)C)S(=O)([O-])=O)=C6/C=C/C(CCC/7)=CC7=C\C=C8C(C)(C)C9=CC(S(=O)(O)=O)=CC=C9N/8C)=O
Biological Activity: PSMA-SulfoCy7 is a high-affinity imaging agent targeting PSMA/GCPII (with a Ki of 18.1 nM for human PSMA). PSMA-SulfoCy7 regulates PSMA-dependent NAAG hydrolysis. PSMA-SulfoCy7 exhibits excellent in vivo imaging capability, enabling clear visualization of PSMA-expressing tumors in xenograft models, with no obvious toxicity even at a dose of 87.9 mg/kg. PSMA-SulfoCy7 is widely used in prostate cancer-related studies[1].
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PSMA-SulfoCy7 | PSMA-SulfoCy7 is a high-affinity imaging agent targeting PSMA/GCPII (with a Ki of 18.1 nM for human PSMA). PSMA-SulfoCy7 regulates PSMA-dependent NAAG hydrolysis. PSMA-SulfoCy7 exhibits excellent in vivo imaging capability, enabling clear visualization of PSMA-expressing tumors in xenograft models, with no obvious toxicity even at a dose of 87.9 mg/kg. PSMA-SulfoCy7 is widely used in prostate cancer-related studies. | |||||||||||||||||||||
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Keywords
