2. Immunology/Inflammation
  3. PSMA
  4. PSMA-SulfoCy7

PSMA-SulfoCy7 is a high-affinity imaging agent targeting PSMA/GCPII (with a Ki of 18.1 nM for human PSMA). PSMA-SulfoCy7 regulates PSMA-dependent NAAG hydrolysis. PSMA-SulfoCy7 exhibits excellent in vivo imaging capability, enabling clear visualization of PSMA-expressing tumors in xenograft models, with no obvious toxicity even at a dose of 87.9 mg/kg. PSMA-SulfoCy7 is widely used in prostate cancer-related studies.

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PSMA-SulfoCy7

PSMA-SulfoCy7 Chemical Structure

CAS No. : 2766510-90-9

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PSMA-SulfoCy7 Related Antibodies

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Description

PSMA-SulfoCy7 is a high-affinity imaging agent targeting PSMA/GCPII (with a Ki of 18.1 nM for human PSMA). PSMA-SulfoCy7 regulates PSMA-dependent NAAG hydrolysis. PSMA-SulfoCy7 exhibits excellent in vivo imaging capability, enabling clear visualization of PSMA-expressing tumors in xenograft models, with no obvious toxicity even at a dose of 87.9 mg/kg. PSMA-SulfoCy7 is widely used in prostate cancer-related studies[1].

In Vitro

PSMA-SulfoCy7 (2 h; 60 min) inhibits PSMA-dependent NAAG hydrolysis in LNCaP cell lysate with a Ki of 18 nM[1].
PSMA-SulfoCy7 is cytotoxic to LNCaP and PC-3 prostate cancer cell lines with CC50 values of 12 μM and 19 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PSMA-SulfoCy7 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: LNCaP and PC-3 prostate cancer cell lines
Concentration: CC50
Incubation Time: /
Result: Inhibited LNCaP and PC-3 prostate cancer cell lines with CC50 values of 12 μM and 19 μM, respectively.
In Vivo

PSMA-SulfoCy7 (250 nmol/kg; i.v.; single dose) demonstrates specific accumulation in PSMA-positive 22Rv1 prostate cancer xenografts, with a twofold higher in vivo fluorescence signal than PSMA-negative PC-3 xenografts at 24 hours post-single intravenous administration of 250 nmol/kg[1].
PSMA-SulfoCy7 (i.v.; single dose) exhibits biphasic elimination from blood plasma in rabbits and rats, with elimination half-lives of 1.39 h and 1.78 h, respectively, and primarily distributes to tissues with elimination via the urinary system[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude mice with Prostate cancer (male, 6-8 week-old, prostate cancer xenograft model)[1]
Dosage: 250 nmol/kg
Administration: i.v.; single dose
Result: Showed no reliable difference in tumor uptake between 22Rv1 and PC-3 xenografts at 0.5, 1, and 8 h post-injection.
Demonstrated a twofold higher fluorescence signal in 22Rv1 tumors compared to PC-3 tumors at 24 h post-injection.
Showed a significant difference in fluorescence signal between 22Rv1 and PC-3 tumors via ex vivo imaging at 24 h post-injection, with clearer distinction against background tissues.
Molecular Weight

1795.51

Formula

C90H112ClN13O20S2
CAS No.
SMILES

O=C([C@@H](NC([C@@H](NC(CCC(NCCCCCC(N(CC1=CC(Cl)=CC=C1)CCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)CC3=CC=C(C=C3)O)NCCCN(N=N4)C=C4CNC(CCCCC[N+](C5=CC=C(C=C5C6(C)C)S(=O)([O-])=O)=C6/C=C/C(CCC/7)=CC7=C\C=C8C(C)(C)C9=CC(S(=O)(O)=O)=CC=C9N/8C)=O
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PSMA-SulfoCy7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSMA-SulfoCy72766510-90-9PSMAProstate-specific membrane antigenxenograftsmiceprostate cancerGCPIILNCaP cell lysatePC-322Rv1NAAGLNCaPInhibitorinhibitorinhibit

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