2767369-80-0
2767369-80-0
Chemical Structure
NLRP3-IN-14
- CAS No.: 2767369-80-0
- Formula:C27H28N2O4
- Molecular Weight:444.52
IUPAC Name: 3-methyl-11-(3-morpholinopropyl)-9,10,11,12-tetrahydrophenanthro[2',1':4,5]furo[2,3-c]pyridine-7,8-dione
InChIKey: YKKLCIHTCPISDO-UHFFFAOYSA-N
SMILES: CC1=C2C=CC3=C(C2=CC=C1)C(C(C4=C3OC5=C4CCN(C5)CCCN6CCOCC6)=O)=O
Biological Activity: NLRP3-IN-14 is a potent and selective NLRP3 inflammasome inhibitor (KD: 5.87 μM). NLRP3-IN-14 inhibits IL-1β release with an IC50 of 0.131 μM. NLRP3-IN-14 can be used for the research of inflammation[1].
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NLRP3-IN-14 | NLRP3-IN-14 is a potent and selective NLRP3 inflammasome inhibitor (KD: 5.87 μM). NLRP3-IN-14 inhibits IL-1β release with an IC50 of 0.131 μM. NLRP3-IN-14 can be used for the research of inflammation. | |||||||||||||||||||||
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References
Keywords
