2767560-51-8
2767560-51-8
Chemical Structure
A2AAR/HDAC-IN-1
- CAS No.: 2767560-51-8
- Formula:C24H21N7O2
- Molecular Weight:439.47
IUPAC Name: 4-(2-(6-amino-4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-N-(2-aminophenyl)benzamide
InChIKey: BENMZDAJCRYRCC-UHFFFAOYSA-N
SMILES: NC1=CC=CC=C1NC(C2=CC=C(C=C2)CCN3N=CC4=C(N=C(N=C43)N)C5=CC=CO5)=O
Biological Activity: A2AAR/HDAC-IN-1 (compound 14c) is an orally active, potent and balanced A2AAR/HDAC dual inhibitor, with a Ki of 163.5 nM for A2AAR and an IC50 of 145.3 nM for HDAC1. A2AAR/HDAC-IN-1 shows anticancer activity[1].
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A2AAR/HDAC-IN-1 | A2AAR/HDAC-IN-1 (compound 14c) is an orally active, potent and balanced A2AAR/HDAC dual inhibitor, with a Ki of 163.5 nM for A2AAR and an IC50 of 145.3 nM for HDAC1. A2AAR/HDAC-IN-1 shows anticancer activity. | |||||||||||||||||||||
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References
Keywords
