2769107-89-1
2769107-89-1
Chemical Structure
MK-1468
- CAS No.: 2769107-89-1
- Formula:C26H33ClN4O4
- Molecular Weight:501.02
InChIKey: ISEBFQYGEPKLRU-RZTXVSJASA-N
SMILES: ClC(C(N1CCN([C@]2([C@H](COC2)O)C)CC1)=C3)=CC(C=N4)=C3C=C4NC([C@@H]5C6(CCOCC6)C5)=O
Biological Activity: MK-1468 is an orally active, selective, and BBB-permeable LRRK2 inhibitor. MK-1468 can be used for the research of Parkinson's disease[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
MK-1468 | 99.69% | MK-1468 is an orally active, selective, and BBB-permeable LRRK2 inhibitor. MK-1468 can be used for the research of Parkinson's disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Kattar SD, et al. Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease. J Med Chem. 2023 Oct 20. [Content Brief]
- [2]. Miller GK, et al. Effects of LRRK2 Inhibitors in Nonhuman Primates. Toxicol Pathol. 2023 Jul;51(5):232-245. [Content Brief]
