27783-53-5
Chemical Structure
Deacetyl acebutolol
- CAS No.: 27783-53-5
- Formula:C16H26N2O3
- Molecular Weight:294.40
IUPAC Name: N-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)butyramide
InChIKey: SZQPDJRQGAJVTI-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(OCC(O)CNC(C)C)C=C1)CCC
Biological Activity: Deacetyl acebutolol is a disinfection by-product and in vivo deacetylated metabolite of Acebutolol (HY-17497). Deacetyl acebutolol is generated from Acebutolol via a series of reactions including chlorination, dealkylation, hydroxylation and oxidation. In vivo, Deacetyl acebutolol is produced by the carboxylesterase CES2-catalyzed hydrolysis of Acebutolol. Deacetyl acebutolol can be used in the research of arrhythmia [1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Deacetyl acebutolol | Deacetyl acebutolol is a disinfection by-product and in vivo deacetylated metabolite of Acebutolol (HY-17497). Deacetyl acebutolol is generated from Acebutolol via a series of reactions including chlorination, dealkylation, hydroxylation and oxidation. In vivo, Deacetyl acebutolol is produced by the carboxylesterase CES2-catalyzed hydrolysis of Acebutolol. Deacetyl acebutolol can be used in the research of arrhythmia . | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Richardson S D, et al. Liquid chromatography–mass spectrometry of emerging disinfection by-products[M]//Comprehensive Analytical Chemistry. Elsevier, 2018, 79: 267-295.
- [2]. Fukami T, et al. Non-P450 drug-metabolizing enzymes: contribution to drug disposition, toxicity, and development[J]. Annual Review of Pharmacology and Toxicology, 2022, 62: 405-425.
