2796227-17-1
Chemical Structure
S-Ac7-DOg
- CAS 番号: 2796227-17-1
- Formula:C53H97N3O8S2
- Molecular Weight:968.48
InChIKey: XGPBIFSAQSHYAK-CLFAGFIQSA-N
SMILES: CCCCCCCC/C=C\CCCCCCCC(OCC(OC(CCCCCCC/C=C\CCCCCCCC)=O)CNC(OCCSSCCOC(NCCN1CCCCCC1)=O)=O)=O
Biological Activity: S-Ac7-DOG is a cationic lipid with biodegradability, low immunogenicity and high nucleic acid transfection capacity, which is commonly used to construct lipid nanoparticles for nucleic acid molecule delivery. S-Ac7-DOG can bind to mRNA, microRNA and self-amplifying RNA through electrostatic interaction. Lipid nanoparticles formed by S-Ac7-DOG enter cells via an energy-dependent endocytic pathway, release nucleic acid cargos, induce antigen-specific CD8+ T cell responses, promote the generation of precursor memory T cells, and regulate neuroinflammatory pathways. S-Ac7-DOG can be used in the research of retinal diseases, neuroinflammation and cancer[1][2][3][4].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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S-Ac7-DOg | 99.69% | S-Ac7-DOG is a cationic lipid with biodegradability, low immunogenicity and high nucleic acid transfection capacity, which is commonly used to construct lipid nanoparticles for nucleic acid molecule delivery. S-Ac7-DOG can bind to mRNA, microRNA and self-amplifying RNA through electrostatic interaction. Lipid nanoparticles formed by S-Ac7-DOG enter cells via an energy-dependent endocytic pathway, release nucleic acid cargos, induce antigen-specific CD8+ T cell responses, promote the generation of precursor memory T cells, and regulate neuroinflammatory pathways. S-Ac7-DOG can be used in the research of retinal diseases, neuroinflammation and cancer. | ||||||||||||||||||||
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References
- [1]. Li W, et al. Efficacy versus immunogenicity of LNP-mediated delivery of mRNA and self-amplifying RNA upon intravitreal injection in the mouse eye. J Control Release. 2025;385:114027. [Content Brief]
- [2]. Ma Z, et al. Lipid nanoparticle-mediated delivery of microRNA-124 reduces neuroinflammation. Biomaterials. 2026;325:123589. [Content Brief]
- [3]. De Lombaerde E, et al. Combinatorial Screening of Biscarbamate Ionizable Lipids Identifies a Low Reactogenicity Lipid for Lipid Nanoparticle mRNA Delivery. Adv Funct Mater. 2024 Feb 01;34(21):2310623.
- [4]. Wang H, et al. Admixing of mRNA with Pre-Formed Lipid Nanoparticles Containing a Slightly-Cationic Ionizable Lipid Allows for Efficient mRNA Transfection In Vitro and In Vivo. Adv Healthc Mater. 2025;14(23):e2501788. [Content Brief]
