2797973-69-2
Chemical Structure
(S)-c-Kit-IN-12
- CAS No.: 2797973-69-2
- Formula:C24H20F3N5O3S
- Molecular Weight:515.51
IUPAC Name: (S)-N-(3-((2-(3-hydroxypyrrolidine-1-carboxamido)thiazol-5-yl)ethynyl)-4-methylphenyl)-4-(trifluoromethyl)picolinamide
InChIKey: RQVOIGFWZRHTCB-SFHVURJKSA-N
SMILES: C(NC1=CC(C#CC=2SC(NC(=O)N3C[C@@H](O)CC3)=NC2)=C(C)C=C1)(=O)C4=CC(C(F)(F)F)=CC=N4
Biological Activity: (S)-c-Kit-IN-12 (Compound 2b) is a potent c-Kit inhibitor, with its IC50 value for c-Kit being less than 10 nM in four KIT mutant cell models (BAF3 KIT EX11 DEL, EX11 DEL/D816H, EX11 DEL/T670I, EX11 DEL/V654A). (S)-c-Kit-IN-12 can be used for studying diseases or disorders related to c-Kit, such as cancer[1].
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(S)-c-Kit-IN-12 | (S)-c-Kit-IN-12 (Compound 2b) is a potent c-Kit inhibitor, with its IC50 value for c-Kit being less than 10 nM in four KIT mutant cell models (BAF3 KIT EX11 DEL, EX11 DEL/D816H, EX11 DEL/T670I, EX11 DEL/V654A). (S)-c-Kit-IN-12 can be used for studying diseases or disorders related to c-Kit, such as cancer. | |||||||||||||||||||||
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