(S)-c-Kit-IN-12
(S)-c-Kit-IN-12 (Compound 2b) is a potent c-Kit inhibitor, with its IC50 value for c-Kit being less than 10 nM in four KIT mutant cell models (BAF3 KIT EX11 DEL, EX11 DEL/D816H, EX11 DEL/T670I, EX11 DEL/V654A). (S)-c-Kit-IN-12 can be used for studying diseases or disorders related to c-Kit, such as cancer.
For research use only. We do not sell to patients.
- CAS No.: 2797973-69-2
- Formula: C24H20F3N5O3S
- Molecular Weight:515.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Chemical Information
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CAS No. 2797973-69-2
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Molecular Weight 515.51
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Formula C24H20F3N5O3S
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SMILES
C(NC1=CC(C#CC=2SC(NC(=O)N3C[C@@H](O)CC3)=NC2)=C(C)C=C1)(=O)C4=CC(C(F)(F)F)=CC=N4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)