c-Kit-IN-12
C-Kit-IN-12 (Compound 2a) is a potent c-Kit inhibitor, with its IC50 value for c-Kit being less than 10 nM in four KIT mutant cell models (BAF3 KIT EX11 DEL, EX11 DEL/D816H, EX11 DEL/T670I, EX11 DEL/V654A). C-Kit-IN-12 can be used for studying diseases or disorders related to c-Kit, such as cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 2797973-68-1
- Formel: C24H20F3N5O3S
- Molecular Weight:515.51
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 2797973-68-1
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Molecular Weight 515.51
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Formel C24H20F3N5O3S
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SMILES
C(NC1=CC(C#CC=2SC(NC(=O)N3C[C@H](O)CC3)=NC2)=C(C)C=C1)(=O)C4=CC(C(F)(F)F)=CC=N4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)