2803329-86-2
Chemical Structure
JAK3-IN-13
- CAS No.: 2803329-86-2
- Formula:C25H33ClN6O5
- Molecular Weight:533.02
IUPAC Name: N-(5-((5-chloro-4-(((3R,3aR,6R,6aR)-6-methoxyhexahydrofuro[3,2-b]furan-3-yl)oxy)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)acrylamide
InChIKey: MXXJXRACSRJBKS-OHUMZHCVSA-N
SMILES: C=CC(NC1=CC(NC2=NC=C(Cl)C(O[C@H]3[C@](OC[C@H]4OC)([H])[C@]4([H])OC3)=N2)=CC=C1N(CCN(C)C)C)=O
Biological Activity: JAK3-IN-13 (compound 12n) is a potent, selective and orally active JAK3 inhibitor with IC50 values of 4728, 2039, 8, 365 nM for NK1, JNK2, JNK3, Tyk2, respectively. JAK3-IN-13 shows antiproliferative activity. JAK3-IN-13 induces cell cycle arrest at G0/G1 phase. JAK3-IN-13 shows antitumor activity[1].
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JAK3-IN-13 | JAK3-IN-13 (compound 12n) is a potent, selective and orally active JAK3 inhibitor with IC50 values of 4728, 2039, 8, 365 nM for NK1, JNK2, JNK3, Tyk2, respectively. JAK3-IN-13 shows antiproliferative activity. JAK3-IN-13 induces cell cycle arrest at G0/G1 phase. JAK3-IN-13 shows antitumor activity. | |||||||||||||||||||||
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Keywords
