2803411-76-7
Chemical Structure
Difelikefalin acetate
Synonym(s): CR-845 acetate; FE-202845 acetate
- CAS No.: 2803411-76-7
- Formula:C38H57N7O8
- Molecular Weight:739.90
InChIKey: MZWHRPKAHCWTOI-KGURMGBCSA-N
SMILES: CC(O)=O.O=C(C1(N)CCN(C([C@@H](CCCCN)NC([C@@H](CC(C)C)NC([C@@H](CC2=CC=CC=C2)NC([C@@H](CC3=CC=CC=C3)N)=O)=O)=O)=O)CC1)O
Biological Activity: Difelikefalin acetate (CR-845 acetate; FE-202845 acetate) is an orally active peripherally acting kappa opioid receptor agonist. Difelikefalin acetate reduces acute kidney injury, decreases oliguria, maintains urine flow, inhibits cytokine expression, and improves survival in endotoxemia after ischemia/reperfusion. Difelikefalin acetate suppresses pruritus signals and exhibits neuromodulatory antipruritic activity. Difelikefalin acetate can be used in research related to acute kidney injury, chronic kidney disease-associated pruritus, and atopic dermatitis[1][2][3].
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Difelikefalin acetate | Difelikefalin acetate (CR-845 acetate; FE-202845 acetate) is an orally active peripherally acting kappa opioid receptor agonist. Difelikefalin acetate reduces acute kidney injury, decreases oliguria, maintains urine flow, inhibits cytokine expression, and improves survival in endotoxemia after ischemia/reperfusion. Difelikefalin acetate suppresses pruritus signals and exhibits neuromodulatory antipruritic activity. Difelikefalin acetate can be used in research related to acute kidney injury, chronic kidney disease-associated pruritus, and atopic dermatitis. | |||||||||||||||||||||
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- [1]. Sawanobori Y, et al. A kappa opioid receptor agonist, difelikefalin, improves acute kidney injury in experimental sepsis models. PloS one. 2026;21(4):e0343693. [Content Brief]
- [2]. Viscusi ER, et al. Effect of difelikefalin, a selective kappa opioid receptor agonist, on respiratory depression: A randomized, double-blind, placebo-controlled trial. Clinical and translational science. 2021 Sep;14(5):1886-1893. [Content Brief]
- [3]. Tamari M, et al. Difelikefalin suppresses itch and reduces scratching independent of inflammation in a murine model of atopic dermatitis. The Journal of allergy and clinical immunology. 2023 Oct;152(4):927-932. [Content Brief]
Keywords
