2803951-18-8
2803951-18-8
Chemical Structure
URAT1 inhibitor 2
- CAS No.: 2803951-18-8
- Formula:C21H18BrN3O2S
- Molecular Weight:456.36
IUPAC Name: 2-((1-((4-bromonaphthalen-1-yl)methyl)-1H-imidazo[4,5-b]pyridin-2-yl)thio)-2-methylpropanoic acid
InChIKey: VKHXJKYGFGXZSS-UHFFFAOYSA-N
SMILES: O=C(C(C)(SC1=NC2=NC=CC=C2N1CC3=C4C=CC=CC4=C(C=C3)Br)C)O
Biological Activity: URAT1 inhibitor 2 is an orally active and potent URAT1 and CYP isozyme inhibitor, with IC50 values of 1.36 μM, 16.97 μM, 5.22 μM for URAT1-mediated 14C-UA uptake, CYP1A2 and CYP2C9, respectively. URAT1 inhibitor 2 is a promising agent candidate in the study of hyperuricemia and gout[1].
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URAT1 inhibitor 2 | URAT1 inhibitor 2 is an orally active and potent URAT1 and CYP isozyme inhibitor, with IC50 values of 1.36 μM, 16.97 μM, 5.22 μM for URAT1-mediated 14C-UA uptake, CYP1A2 and CYP2C9, respectively. URAT1 inhibitor 2 is a promising agent candidate in the study of hyperuricemia and gout. | |||||||||||||||||||||
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