2809367-71-1
Chemical Structure
DDO-6513
- CAS No.: 2809367-71-1
- Formula:C20H18ClNO4
- Molecular Weight:371.81
InChIKey: TUQUJRSTUJVFNH-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC(C2=CC=C(C(C)(C)C)C=C2)=O)C3=CC(Cl)=CC=C3O1)O
Biological Activity: DDO-6513 is a STING molecular glue inhibitor with an IC50 of 1.93 μM. DDO-6513 selectively targets human STING but not murine STING, and exhibits a Kd value of 151 nM for human STING. DDO-6513 induces aberrant head-to-head STING oligomerization and disrupts the formation of normal signal-competent linear STING polymers. DDO-6513 inhibits STING-dependent downstream activation of TBK1 and IRF3, and suppresses the expression of proinflammatory cytokines. DDO-6513 can be used for research on STING-related autoinflammatory diseases[1].
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DDO-6513 | DDO-6513 is a STING molecular glue inhibitor with an IC50 of 1.93 μM. DDO-6513 selectively targets human STING but not murine STING, and exhibits a Kd value of 151 nM for human STING. DDO-6513 induces aberrant head-to-head STING oligomerization and disrupts the formation of normal signal-competent linear STING polymers. DDO-6513 inhibits STING-dependent downstream activation of TBK1 and IRF3, and suppresses the expression of proinflammatory cytokines. DDO-6513 can be used for research on STING-related autoinflammatory diseases. | |||||||||||||||||||||
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