2820126-50-7
Chemical Structure
EGFR/HER2-IN-6
- CAS No.: 2820126-50-7
- Formula:C18H21N5O3S
- Molecular Weight:387.46
IUPAC Name: 5-(4-methoxyphenyl)-6-(morpholinomethyl)imidazo[2,1-b]thiazole-3-carbohydrazide
InChIKey: ADWBIWIWVFJDMV-UHFFFAOYSA-N
SMILES: O=C(C1=CSC2=NC(CN3CCOCC3)=C(C4=CC=C(OC)C=C4)N21)NN
Biological Activity: EGFR/HER2-IN-6 (compound 43) is an EGFR/HER2 and DHFR inhibitor. EGFR/HER2-IN-6 inhibits EGFR kinase, HER2 kinase and DHFR with IC50s of 0.122, 0.078 and 0.585 μM, respectively. EGFR/HER2-IN-6 shows anticancer activity against several cancer cell lines with high safety profile and selectivity indices. EGFR/HER2-IN-8 can be used for the research of cancer[1].
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EGFR/HER2-IN-6 | EGFR/HER2-IN-6 (compound 43) is an EGFR/HER2 and DHFR inhibitor. EGFR/HER2-IN-6 inhibits EGFR kinase, HER2 kinase and DHFR with IC50s of 0.122, 0.078 and 0.585 μM, respectively. EGFR/HER2-IN-6 shows anticancer activity against several cancer cell lines with high safety profile and selectivity indices. EGFR/HER2-IN-8 can be used for the research of cancer. | |||||||||||||||||||||
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Keywords
