2820286-56-2
Chemical Structure
Anticancer agent 81
- CAS No.: 2820286-56-2
- Formula:C46H46N6O5
- Molecular Weight:762.89
IUPAC Name: (S)-2-(2-(4-(5-((2-(4-aminophenyl)-7-methoxy-5-oxo-5,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)pentyl)piperazin-1-yl)ethyl)-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione
InChIKey: OQPINPWCKSKRPT-DHUJRADRSA-N
SMILES: O=C1N(CCN2CCN(CCCCCOC3=C(OC)C=C4C(N=C[C@@](CC(C5=CC=C(N)C=C5)=C6)([H])N6C4=O)=C3)CC2)C(C7=CC=CC8=CC9=CC=CC=C9C1=C78)=O
Biological Activity: Anticancer agent 81 (Compound 37b3) is an anticancer agent and can induce tumor cell cycle arrest and apoptosis. Anticancer agent 81 can be used as a payload to conjugate with Trastuzumab (HY-P9907) to obtain the antibody–agent conjugate (ADC) T-PBA. T-PBA maintained its mode of target and internalization ability of Trastuzumab[1].
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Anticancer agent 81 | Anticancer agent 81 (Compound 37b3) is an anticancer agent and can induce tumor cell cycle arrest and apoptosis. Anticancer agent 81 can be used as a payload to conjugate with Trastuzumab (HY-P9907) to obtain the antibody–agent conjugate (ADC) T-PBA. T-PBA maintained its mode of target and internalization ability of Trastuzumab. | |||||||||||||||||||||
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