2839142-69-5
Chemical Structure
SC13
- CAS No.: 2839142-69-5
- Formula:C26H30N2O5
- Molecular Weight:450.53
IUPAC Name: methyl (E)-2-((2S,3S,7aS,12bS)-3-ethyl-8-(furan-3-yl)-7a-hydroxy-1,2,3,4,6,7,7a,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate
InChIKey: XLDZPTJGCMJSBF-BHKYNAABSA-N
SMILES: O=C(OC)/C([C@@H](C[C@]12[H])[C@H](CC)CN1CC[C@@]3(O)C2=NC4=C3C(C5=COC=C5)=CC=C4)=C/OC
Biological Activity: SC13 is an orally active, selective Flap structure-specific endonuclease 1 (FEN1) inhibitor and mu opioid receptor (MOR) activator. SC13 impairs DNA damage repair and induces apoptosis in cancer cells. SC13 activates cGAS-STING signaling, increases chemokine secretion, and promotes CAR-T cell infiltration at solid tumour sites. SC13 can be used for the research of solid tumours and pain[1][2].
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SC13 | SC13 is an orally active, selective Flap structure-specific endonuclease 1 (FEN1) inhibitor and mu opioid receptor (MOR) activator. SC13 impairs DNA damage repair and induces apoptosis in cancer cells. SC13 activates cGAS-STING signaling, increases chemokine secretion, and promotes CAR-T cell infiltration at solid tumour sites. SC13 can be used for the research of solid tumours and pain. | |||||||||||||||||||||
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- [1]. Dong Y, et al. FEN1 inhibitor SC13 promotes CAR-T cells infiltration into solid tumours through cGAS-STING signalling pathway. Immunology. 2023;170(3):388-400. [Content Brief]
- [2]. Chakraborty S, et al. A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects. J Med Chem. 2021;64(18):13873-13892. [Content Brief]
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