2841308-96-9
2841308-96-9
Chemical Structure
PROTAC AR/AR-V7 degrader-1
- CAS No.: 2841308-96-9
- Formula:C24H19F4N5O2
- Molecular Weight:485.43
InChIKey: QMRZVTDYXXBISG-UHFFFAOYSA-N
SMILES: O=C1C(C)(C)N(CCNC2=C(C=CC=N3)C3=C(F)C=C2)C(N1C4=CC(C(F)(F)F)=C(C#N)C=C4)=O
Biological Activity:
PROTAC AR/AR-V7 degrader-1 (27c) is a PROTAC-based and dual AR, AR-V7 degrader, with DC50 values of 2.67 and 2.64 μM for AR and AR-V7, respectively. PROTAC AR/AR-V7 degrader-1 (27c) induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PROTAC AR/AR-V7 degrader-1 | 99.72% | PROTAC AR/AR-V7 degrader-1 (27c) is a PROTAC-based and dual AR, AR-V7 degrader, with DC50 values of 2.67 and 2.64 μM for AR and AR-V7, respectively. PROTAC AR/AR-V7 degrader-1 (27c) induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker). |
||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.61
HY-10561RU 58841 -
Similarity Score 0.59
HY-120703RU 58642 -
Similarity Score 0.55
HY-70002Enzalutamide -
Similarity Score 0.55
HY-70002BREnzalutamide carboxylic acid (Standard) -
Similarity Score 0.55
HY-70002ARN-Desmethyl enzalutamide (Standard) -
Similarity Score 0.55
HY-18102GLPG0492 -
Similarity Score 0.55
HY-18102AGLPG0492 (R enantiomer) -
Similarity Score 0.55
HY-131388ABM-14 -
Similarity Score 0.54
HY-70002SDeutenzalutamide-d3 -
Explore the MedChemAI to find more analogs
