2841455-91-0
2841455-91-0
Chemical Structure
Topo I/COX-2-IN-2
- CAS. Nr.: 2841455-91-0
- Formula:C24H25ClN4O
- Molecular Weight:420.93
IUPAC Name: 2-((3-chloro-2-methylphenyl)amino)-N-(4-(piperazin-1-yl)phenyl)benzamide
InChIKey: JBNHQJVJLARADC-UHFFFAOYSA-N
SMILES: ClC1=C(C(NC2=CC=CC=C2C(NC3=CC=C(C=C3)N4CCNCC4)=O)=CC=C1)C
Biological Activity: Topo I/COX-2-IN-2 (Compound W10) is a potent dual-target inhibitor of Topo I and COX-2 with IC50 values of 0.90 μM and 2.31 μM, respectively. Topo I/COX-2-IN-2 induces cancer cell apoptosis through the mitochondrial pathway[1].
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Topo I/COX-2-IN-2 | Topo I/COX-2-IN-2 (Compound W10) is a potent dual-target inhibitor of Topo I and COX-2 with IC50 values of 0.90 μM and 2.31 μM, respectively. Topo I/COX-2-IN-2 induces cancer cell apoptosis through the mitochondrial pathway. | |||||||||||||||||||||
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