2843557-76-4
Chemical Structure
NMB-1
- CAS No.: 2843557-76-4
- Formula:C111H164N36O21S4
- Molecular Weight:2466.98
InChIKey: DWDRIWQVJMGMNY-KJGHYZMMSA-N
SMILES: O=C([C@@H](N)CC1=CC=CC=C1)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H]3CCC2)=O)[C@H](CC)C)=O)CC(C)C)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]4CC5=CC=CC=C5)=O)CC6=CC=CC=C6)=O)CCCCN)=O)CCCCN)=O)CC7=CNC=N7)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)CSSC[C@H](NC4=O)C(N)=O)=O)CCCNC(N)=N)=O)CC8=CNC9=CC=CC=C89)=O)CC(N)=O
Biological Activity: NMB-1 is a cone peptide analog and a mechanosensitive current inhibitor. NMB-1 selectively inhibits sustained mechanically activated currents in sensory neurons, with an IC50 of 1 μM. NMB-1 inhibits mechanical pain. NMB-1 selectively raises high-threshold pressure nociceptive thresholds in rats. NMB-1 can be used in research on mechanically evoked pain and auditory dysfunction[1][2][3].
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NMB-1 | NMB-1 is a cone peptide analog and a mechanosensitive current inhibitor. NMB-1 selectively inhibits sustained mechanically activated currents in sensory neurons, with an IC50 of 1 μM. NMB-1 inhibits mechanical pain. NMB-1 selectively raises high-threshold pressure nociceptive thresholds in rats. NMB-1 can be used in research on mechanically evoked pain and auditory dysfunction. | |||||||||||||||||||||
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References
- [1]. Raouf R, et al. Inhibition of somatosensory mechanotransduction by annexin A6. Science signaling. 2018 Jun 19;11(535):eaao2060. [Content Brief]
- [2]. Drew LJ, et al. High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PloS one. 2007 Jun 13;2(6):e515. [Content Brief]
- [3]. Lim S, et al. Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB-1. British journal of pharmacology. 2026 May;183(9):1845-1859. [Content Brief]
