2851895-01-5
2851895-01-5
Chemical Structure
GAT564
- CAS No.: 2851895-01-5
- Formula:C20H16N2O2S
- Molecular Weight:348.42
IUPAC Name: 3-(2-nitro-1-phenylethyl)-2-(thiophen-3-yl)-1H-indole
InChIKey: NCOQFHIDDWOEMQ-UHFFFAOYSA-N
SMILES: O=[N+](CC(C1=C(NC2=CC=CC=C21)C3=CSC=C3)C4=CC=CC=C4)[O-]
Biological Activity: GAT564 (Compound 15d) is a potent allosteric modulator of cannabinoid 1 receptor (CB1R) with EC50s of 87 and 320 nM respectively for cAMP and β-arrestin2. GAT564 markedly promotes orthosteric ligand binding to hCB1R. GAT564 is efficacious as a topical agent that significantly reduces intraocular pressure (IOP) in the ocular normotensive murine model of glaucoma[1].
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GAT564 | GAT564 (Compound 15d) is a potent allosteric modulator of cannabinoid 1 receptor (CB1R) with EC50s of 87 and 320 nM respectively for cAMP and β-arrestin2. GAT564 markedly promotes orthosteric ligand binding to hCB1R. GAT564 is efficacious as a topical agent that significantly reduces intraocular pressure (IOP) in the ocular normotensive murine model of glaucoma. | |||||||||||||||||||||
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