2851986-77-9
Chemical Structure
PLX-4104
- CAS No.: 2851986-77-9
- Formula:C32H26FN9O2S
- Molecular Weight:619.67
InChIKey: ZYHRJTQTUOKUIR-VWLOTQADSA-N
SMILES: O=C(NC1=C(F)C=CC(C2=CC=C(C3=N[C@@H](CC(N)=O)C4=NN=C(C)N4C5=C3C(C)=C(C)S5)C=C2)=C1)C6=C7N=CC=CN7N=C6
Biological Activity: PLX-4104 is an orally active BRD4 molecular glue degrader with a DC50 of 2 nM. PLX-4104 selectively promotes BRD4 degradation via DCAF11 recruitment, triggering ubiquitination and proteasomal breakdown. PLX-4104 inhibits cancer cell proliferation. PLX-4104 induces complete regression of AML xenograft tumors. PLX-4104 can be used for the research of acute myeloid leukemia[1].
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PLX-4104 | PLX-4104 is an orally active BRD4 molecular glue degrader with a DC50 of 2 nM. PLX-4104 selectively promotes BRD4 degradation via DCAF11 recruitment, triggering ubiquitination and proteasomal breakdown. PLX-4104 inhibits cancer cell proliferation. PLX-4104 induces complete regression of AML xenograft tumors. PLX-4104 can be used for the research of acute myeloid leukemia. | |||||||||||||||||||||
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Keywords
