2855099-87-3
Chemical Structure
Acremonamide
- CAS No.: 2855099-87-3
- Formula:C33H44N4O6
- Molecular Weight:592.74
IUPAC Name: (3S,6S,9S,12S,15R)-6,9-dibenzyl-12,15-diisopropyl-3,4,10-trimethyl-1-oxa-4,7,10,13-tetraazacyclopentadecane-2,5,8,11,14-pentaone
InChIKey: AJUDPIHREOSQGT-CPFCZLQXSA-N
SMILES: C([C@H]1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N(C)[C@@H](C)C(=O)O[C@H]([C@H](C)C)C(=O)N[C@@H](C(C)C)C(=O)N1C)C3=CC=CC=C3
Biological Activity: Acremonamide is a cyclic pentapeptide lactone discovered from the marine-derived Acremonium strain CNQ-049, possessing wound healing activity. Acremonamide upregulates the expression of COL1A2 and ACTC1 genes and enhances the motility of keratinocytes and fibroblasts. Acremonamide promotes wound healing in mouse skin wound models. Acremonamide can be used in research related to skin wound healing[1][2].
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Acremonamide | Acremonamide is a cyclic pentapeptide lactone discovered from the marine-derived Acremonium strain CNQ-049, possessing wound healing activity. Acremonamide upregulates the expression of COL1A2 and ACTC1 genes and enhances the motility of keratinocytes and fibroblasts. Acremonamide promotes wound healing in mouse skin wound models. Acremonamide can be used in research related to skin wound healing. | |||||||||||||||||||||
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References
- [1]. Zhang T, et al. Hydrogels Loaded with Bioactive Peptides for Wound Repair. Journal of agricultural and food chemistry. 2026 Jul 29;74(29):22393-22408.
- [2]. Kim S, et al. Acremonamide, a Cyclic Pentadepsipeptide with Wound-Healing Properties Isolated from a Marine-Derived Fungus of the Genus . Journal of natural products. 2021 Aug 27;84(8):2249-2255.
