2857982-34-2
2857982-34-2
Chemical Structure
TTBK1/2-IN-3
- CAS No.: 2857982-34-2
- Formula:C21H22N4O
- Molecular Weight:346.43
InChIKey: ALQLTPNCVCECNJ-UHFFFAOYSA-N
SMILES: CC(CC)(O)C#CC1=CC2=C(NC3=C2C4=C(C=NC(N)=N4)CCC3)C=C1
Biological Activity: TTBK1/2-IN-3 (Compound 10) is a potent inhibitor of tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 inhibits the phosphorylation of TDP-43. TTBK1/2-IN-3 reduces the expression of primary cilia on the surface of iPSCs[1].
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TTBK1/2-IN-3 | TTBK1/2-IN-3 (Compound 10) is a potent inhibitor of tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 inhibits the phosphorylation of TDP-43. TTBK1/2-IN-3 reduces the expression of primary cilia on the surface of iPSCs. | |||||||||||||||||||||
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