28714-26-3
28714-26-3
Chemical Structure
Aerothionin
- CAS No.: 28714-26-3
- Formula:C24H26Br4N4O8
- Molecular Weight:818.10
IUPAC Name: (5S,5'S,10R,10'R)-N,N'-(butane-1,4-diyl)bis(7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-triene-3-carboxamide)
InChIKey: BJWQSQOWGBUSFC-UWXQAFAOSA-N
SMILES: O[C@@H]1[C@@]2(C=C(C(OC)=C1Br)Br)CC(C(NCCCCNC(C3=NO[C@@]4([C@H](C(Br)=C(C(Br)=C4)OC)O)C3)=O)=O)=NO2
Biological Activity: Aerothionin is an antibiotic with potent antimicrobial efficacy against bacteria and fungi. Aerothionin exhibits antitumor efficacy against adrenal pheochromocytomas and extra-adrenal paragangliomas (PPGLs)[1][2].
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Aerothionin | Aerothionin is an antibiotic with potent antimicrobial efficacy against bacteria and fungi. Aerothionin exhibits antitumor efficacy against adrenal pheochromocytomas and extra-adrenal paragangliomas (PPGLs). | |||||||||||||||||||||
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References
- [1]. Drechsel A, et al., Anti-Tumor Activity vs. Normal Cell Toxicity: Therapeutic Potential of the Bromotyrosines Aerothionin and Homoaerothionin In Vitro. Mar Drugs. 2020 May 1;18(5):236. [Content Brief]
- [2]. Šimovičová M. Synthesis of aerothionin analogs as potential antimycobacterial agents[J]. 2021.
