Aerothionin
Aerothionin is an antibiotic with potent antimicrobial efficacy against bacteria and fungi. Aerothionin exhibits antitumor efficacy against adrenal pheochromocytomas and extra-adrenal paragangliomas (PPGLs).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 28714-26-3
- 分子式: C24H26Br4N4O8
- 分子量:818.10
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
>10 μg/mL
Compound: 4
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Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
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[PMID: 17512741] |
| HeLa | EC50 |
42 μM
Compound: 17
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Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
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[PMID: 24631731] |
| HeLa | IC50 |
29 μM
Compound: 2
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Antiproliferative activity against human HeLa cells assessed as cell viability measured after 24 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as cell viability measured after 24 hrs by MTT assay
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[PMID: 33940466] |
| HT-29 | GI50 |
>10 μg/mL
Compound: 4
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Cytotoxicity against human HT29 cells by SRB assay
Cytotoxicity against human HT29 cells by SRB assay
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[PMID: 17512741] |
| MDA-MB-231 | GI50 |
>10 μg/mL
Compound: 4
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Cytotoxicity against human MDA-MB-231 cells by SRB assay
Cytotoxicity against human MDA-MB-231 cells by SRB assay
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[PMID: 17512741] |
体外実験
Aerothionin (0-100 μM, 24h) inhibits prolifeartions of pheochromocytoma cells MPC and MTT, inhibits the MTT spheroid growth (10 μM, single dose)[1].
Aerothionin (0-100 μM, 24h) exhibits toxicity in normal endothelial cells HUVECs, stimulates slightly the viability of normal fibroblasts 3T3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MPC, MTT, HUVECs, 3T3
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Concentration:0-100 μM
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Incubation Time:24 h
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Result:Inhibited proliferations of MPC, MTT and HUVECs, stimulated proliferation of 32T3.
化学情報
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CAS 番号 28714-26-3
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分子量 818.10
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分子式 C24H26Br4N4O8
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SMILES
O[C@@H]1[C@@]2(C=C(C(OC)=C1Br)Br)CC(C(NCCCCNC(C3=NO[C@@]4([C@H](C(Br)=C(C(Br)=C4)OC)O)C3)=O)=O)=NO2
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Structure Classification
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Initial Source
Aplysina fistularis
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Drechsel A, et al., Anti-Tumor Activity vs. Normal Cell Toxicity: Therapeutic Potential of the Bromotyrosines Aerothionin and Homoaerothionin In Vitro. Mar Drugs. 2020 May 1;18(5):236. [Content Brief]
[2]. Šimovičová M. Synthesis of aerothionin analogs as potential antimycobacterial agents[J]. 2021.
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Aerothionin 関連分類
HY-121349 関連分類
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