Cytotoxic dibromotyrosine-derived metabolites from the sponge Aplysina gerardogreeni

  • Bioorg Med Chem. 2007 Aug 1;15(15):5275-82. doi: 10.1016/j.bmc.2007.05.014.
Claudia J Hernández-Guerrero  1 ,  Eva Zubía ,  María J Ortega ,  J Luis Carballo
Affiliations
  • 1. Departamento de Química Orgánica, Facultad de Ciencias del Mar y Ambientales, Universidad de Cádiz, Apdo. 40, 11510-Puerto Real (Cádiz), Spain.
PMID: 17512741 DOI: 10.1016/j.bmc.2007.05.014
Abstract

The chemical study of the Sponge Aplysina gerardogreeni collected at the Gulf of California has led to the isolation of four new dibromotyrosine-derived metabolites, aplysinones A-D, whose structures were determined by spectroscopic analysis and chemical methods. The new compounds and four semisynthetic analogues prepared in this study have shown cytotoxic activity against human tumor cell lines.