287182-52-9
Chemical Structure
RWJ-58643 hydrochloride
- CAS No.: 287182-52-9
- Formula:C20H27ClN6O4S
- Molecular Weight:482.98
InChIKey: RJGFYDAIAYFTCT-BGYHIHCLSA-N
SMILES: O=C([C@H]1N(C[C@@H](C1)O)C(C)=O)NC(CCCNC(N)=N)C(C2=NC3=CC=CC=C3S2)=O.Cl
Biological Activity: RWJ-58643 hydrochloride is a β-trypsin inhibitor that inhibits allergic inflammation. RWJ-58643 hydrochloride (100 mg) significantly reduces nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 hydrochloride causes late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg). RWJ-58643 hydrochloride modulates allergic reactions by inhibiting the release of β-trypsin from mast cells.
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RWJ-58643 hydrochloride | RWJ-58643 hydrochloride is a β-trypsin inhibitor that inhibits allergic inflammation. RWJ-58643 hydrochloride (100 mg) significantly reduces nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 hydrochloride causes late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg). RWJ-58643 hydrochloride modulates allergic reactions by inhibiting the release of β-trypsin from mast cells. | |||||||||||||||||||||
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