2880299-29-4
Chemical Structure
CCR2 ligand-2
- CAS No.: 2880299-29-4
- Formula:C53H48Cl2F3N9O10S
- Molecular Weight:1130.97
InChIKey: YZJAFFGWYUJTLI-UHFFFAOYSA-N
SMILES: O=C(C1=C(C2=C3C=CC(N(C)C)=CC3=[O+]C4=C2C=CC(N(C)C)=C4)C=C(C(NCCOCCOCCN5N=NC(CNC(C6=CC=C(C=C6)OC7=NC=C(C=C7NS(=O)(C8=CC=C(C(C(F)(F)F)=C8)Cl)=O)Cl)=O)=C5)=O)C=C1)[O-]
Biological Activity: CCR2 ligand-2 is a small-molecule fluorescent ligand targeting the intracellular allosteric binding site (IABS) of CCR2, with a Kd value of 266 nM for membrane-based binding affinity and a Kd value of 114 nM for binding affinity in live cells. CCR2 ligand-2 enables non-isotopic, high-throughput cell-free and cell-based NanoBRET binding assays. CCR2 ligand-2 serves as a tool for fragment-based screening strategies[1].
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CCR2 ligand-2 | CCR2 ligand-2 is a small-molecule fluorescent ligand targeting the intracellular allosteric binding site (IABS) of CCR2, with a Kd value of 266 nM for membrane-based binding affinity and a Kd value of 114 nM for binding affinity in live cells. CCR2 ligand-2 enables non-isotopic, high-throughput cell-free and cell-based NanoBRET binding assays. CCR2 ligand-2 serves as a tool for fragment-based screening strategies. | |||||||||||||||||||||
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Keywords
