2883447-45-6
Chemical Structure
AR antagonist 4
- CAS No.: 2883447-45-6
- Formula:C29H36N4O
- Molecular Weight:456.62
IUPAC Name: N-((3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(4-methyl-1H-imidazol-1-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl)isonicotinamide
InChIKey: HJMCKQIXYCUICJ-LMXVXWCUSA-N
SMILES: C[C@@]12[C@](CC=C2N3C=NC(C)=C3)([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](CC5)NC(C6=CC=NC=C6)=O)=CC4)C)([H])CC1
Biological Activity: AR antagonist 4 (Compound 67-b) is an orally active androgen receptor (AR) antagonist with an IC50 of 246.6 nM against wt-AR, and is also an AR degrader with a DC50 of 2.84 μM[1].
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AR antagonist 4 | AR antagonist 4 (Compound 67-b) is an orally active androgen receptor (AR) antagonist with an IC50 of 246.6 nM against wt-AR, and is also an AR degrader with a DC50 of 2.84 μM. | |||||||||||||||||||||
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Keywords
