2883627-65-2
Chemical Structure
α-Synuclein-IN-21
- CAS No.: 2883627-65-2
- Formula:C22H15FN2O4
- Molecular Weight:390.36
InChIKey: ZTTCIXGKLHKKJJ-KGVSQERTSA-N
SMILES: O=C(C1=CC=C(C=C1)F)NC2=CC=C(C=C2)NC(/C=C/C(C(C=C3)=O)=CC3=O)=O
Biological Activity: α-Synuclein-IN-21 is an α-synuclein (α-Syn) aggregation inhibitor with an IC50 of 1.6 μM. α-Synuclein-IN-21 stabilizes the secondary conformation of α-synuclein monomers, inhibits β-sheet formation, reduces oligonucleation during the aggregation lag phase, dissociates preformed aggregates, and blocks re-aggregation. α-Synuclein-IN-21 reduces α-synuclein inclusions in neuronal cells and scavenges ROS. α-Synuclein-IN-21 can be used for the research of Parkinson's disease[1].
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α-Synuclein-IN-21 | α-Synuclein-IN-21 is an α-synuclein (α-Syn) aggregation inhibitor with an IC50 of 1.6 μM. α-Synuclein-IN-21 stabilizes the secondary conformation of α-synuclein monomers, inhibits β-sheet formation, reduces oligonucleation during the aggregation lag phase, dissociates preformed aggregates, and blocks re-aggregation. α-Synuclein-IN-21 reduces α-synuclein inclusions in neuronal cells and scavenges ROS. α-Synuclein-IN-21 can be used for the research of Parkinson's disease. | |||||||||||||||||||||
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Keywords
