2890261-81-9
Chemical Structure
EGFR-IN-61
- CAS No.: 2890261-81-9
- Formula:C33H37ClN8O3
- Molecular Weight:629.15
IUPAC Name: 2-chloro-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((4-(1-(3-hydroxypropyl)-1H-indol-3-yl)pyrimidin-2-yl)amino)-4-methoxyphenyl)isonicotinamide
InChIKey: XELFLRFPUQAHBD-UHFFFAOYSA-N
SMILES: COC1=CC(N(CCN(C)C)C)=C(C=C1NC2=NC(C3=CN(C4=C3C=CC=C4)CCCO)=CC=N2)NC(C5=CC(Cl)=NC=C5)=O
Biological Activity: EGFR-IN-61 (compound 22a) is a potent EGFR kinase inhibitor, with IC50 values of 42 nM (L858R/T790 M), 137 nM (L858R/T790 M/C797S), and 743 nM (WT), respectively. EGFR-IN-61 shows antiproliferative activity against A549 and H1975 cell lines, with IC50 values of 2.14 and 1.82 μM, respectively[1].
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EGFR-IN-61 | EGFR-IN-61 (compound 22a) is a potent EGFR kinase inhibitor, with IC50 values of 42 nM (L858R/T790 M), 137 nM (L858R/T790 M/C797S), and 743 nM (WT), respectively. EGFR-IN-61 shows antiproliferative activity against A549 and H1975 cell lines, with IC50 values of 2.14 and 1.82 μM, respectively. | |||||||||||||||||||||
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