2892016-32-7
Chemical Structure
HIV-1 protease-IN-6
- CAS No.: 2892016-32-7
- Formula:C27H31FN2O6S
- Molecular Weight:530.61
IUPAC Name: N-((2S,3R)-4-((4-fluoro-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-3,5-dihydroxybenzamide
InChIKey: YUYRLUJCQDDJKL-IZZNHLLZSA-N
SMILES: CC(CN(S(=O)(C1=CC=C(C=C1)F)=O)C[C@H]([C@@H](NC(C2=CC(O)=CC(O)=C2)=O)CC3=CC=CC=C3)O)C
Biological Activity: HIV-1 protease-IN-6 (compound 17d) is a potent HIV-1 protease inhibitor, with an IC50 of 21 pM and a Ki of 4.7 pM, respectively. HIV-1 protease-IN-6 exhibits potent antiviral activity to DRV (darunavir)-resistant variant, even more than wild type virus[1].
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HIV-1 protease-IN-6 | HIV-1 protease-IN-6 (compound 17d) is a potent HIV-1 protease inhibitor, with an IC50 of 21 pM and a Ki of 4.7 pM, respectively. HIV-1 protease-IN-6 exhibits potent antiviral activity to DRV (darunavir)-resistant variant, even more than wild type virus. | |||||||||||||||||||||
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Keywords
