2892667-02-4
2892667-02-4
Chemical Structure
Surovatamig
Synonym(s): AZD0486; TNB-486
- CAS No.: 2892667-02-4
- Formula:N/A
- Molecular Weight:(110.46 kDa)
SMILES: [Surovatamig]
Biological Activity: Surovatamig (AZD0486; TNB-486) is a fully human anti-CD19/CD3 IgG4 bispecific antibody. Surovatamig triggers T cell activation, releases cytotoxic granules, and induces T cell-dependent cellular cytotoxicity and tumor cell lysis. Surovatamig can reduces release of pro-inflammatory cytokines including IL-2, IFNγ, TNF. Surovatamig can be used for the research of cancer, such as B cell non-Hodgkin lymphoma[1][2].
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Surovatamig | 99.89% | Surovatamig (AZD0486; TNB-486) is a fully human anti-CD19/CD3 IgG4 bispecific antibody. Surovatamig triggers T cell activation, releases cytotoxic granules, and induces T cell-dependent cellular cytotoxicity and tumor cell lysis. Surovatamig can reduces release of pro-inflammatory cytokines including IL-2, IFNγ, TNF. Surovatamig can be used for the research of cancer, such as B cell non-Hodgkin lymphoma. | ||||||||||||||||||||
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References
- [1]. Malik-Chaudhry HK, et al. TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL. MAbs. 2021;13(1):1890411. [Content Brief]
- [2]. Lin W, et al. Pre-clinical evaluation of surovatamig (AZD0486) in comparison to CD20xCD3 bispecific antibodies[J]. 2025.
