2913176-81-3
Chemical Structure
(4S)-PROTAC SOS1 degrader-1
- CAS No.: 2913176-81-3
- Formula:C57H76ClFN10O4S
- Molecular Weight:1051.79
IUPAC Name: 3-bromo-6,7-dihydro-5H-cyclopenta[b]pyridin-5-amine
InChIKey: AZBRWXRYNYEDKG-UZBSLLNPSA-N
SMILES: O=C(N[C@@H](C(C)(C)C)C(N1C[C@@H](O)C[C@H]1C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)CCCCCCCCN4CCN(CC4)C5=C6N=C(N7CC8(CNC8)C7)N(CC9=CC(C)=C(F)C(C)=C9)C6=CC(Cl)=C5
Biological Activity: (4S)-PROTAC SOS1 degrader-1 is a potent PROTAC SOS1 degrader. (4S)-PROTAC SOS1 degrader-1 decreases the expression of pERK and RAS-GTP level in a dose-dependent manner. (4S)-PROTAC SOS1 degrader-1 significantly inhibits the tumor growth in vivo[1].
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(4S)-PROTAC SOS1 degrader-1 | (4S)-PROTAC SOS1 degrader-1 is a potent PROTAC SOS1 degrader. (4S)-PROTAC SOS1 degrader-1 decreases the expression of pERK and RAS-GTP level in a dose-dependent manner. (4S)-PROTAC SOS1 degrader-1 significantly inhibits the tumor growth in vivo. | |||||||||||||||||||||
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Keywords
