2915567-21-2
2915567-21-2
Chemical Structure
ESC1002755
- CAS No.: 2915567-21-2
- Formula:C21H18ClNO2S
- Molecular Weight:383.89
InChIKey: LIYNBDHGYGCBKM-IBGZPJMESA-N
SMILES: O=C(N1CCC[C@H]1C2=C(C=CC=C2)C3=CC(O)=CC=C3)C4=C(C=CS4)Cl
Biological Activity: ESC1002755 is a 17β-HSD10 inhibitor with an IC50 of 19 nM. ESC1002755 has significant enzyme specificity with non-/uncompetitive inhibition against the cofactor NADH. ESC1002755 shows minimal cytotoxicity towards the HEK293 at 50 μM. ESC1002755 is promising for Alzheimer’s disease and hormone-dependent cancers (such as prostate, bone and colorectal cancer) research[1].
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ESC1002755 | ESC1002755 is a 17β-HSD10 inhibitor with an IC50 of 19 nM. ESC1002755 has significant enzyme specificity with non-/uncompetitive inhibition against the cofactor NADH. ESC1002755 shows minimal cytotoxicity towards the HEK293 at 50 μM. ESC1002755 is promising for Alzheimer’s disease and hormone-dependent cancers (such as prostate, bone and colorectal cancer) research. | |||||||||||||||||||||
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References
Keywords
