2919211-45-1
Chemical Structure
Mazisotine tartrate
Synonym(s): LY3556050 tartrate; CNTX-0290 tartrate
- CAS No.: 2919211-45-1
- Formula:C20H29N3O8
- Molecular Weight:439.46
InChIKey: HADNFKQQXFCLDD-FCIDIOBXSA-N
SMILES: OC([C@H](O)[C@@H](O)C(O)=O)=O.CC(C=CC=N1)=C1OCC(C)(C)NC([C@H]2[C@@]3([H])[C@]2([H])CNC3)=O
Biological Activity: Mazisotine (CNTX-0290) tartrate is an orally active, non-opioid somatostatin receptor 4 (SSTR4) agonist with an EC50 of 4.7 nM. Mazisotine tartrate exerts significant analgesic effects in various nociceptive (inflammatory, osteoarthritic) and neuropathic pain models. Mazisotine tartrate can be used for pain research[1][2].
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Mazisotine tartrate | Mazisotine (CNTX-0290) tartrate is an orally active, non-opioid somatostatin receptor 4 (SSTR4) agonist with an EC50 of 4.7 nM. Mazisotine tartrate exerts significant analgesic effects in various nociceptive (inflammatory, osteoarthritic) and neuropathic pain models. Mazisotine tartrate can be used for pain research. | |||||||||||||||||||||
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- [1]. Nguyen TH, et al. Diastereoselective Cyclopropanation with Secondary Diazoacetamides to Access endo-Azabicyclo[3.1.0]hexane-6-carboxamides. Org Lett. Published online February 23, 2026. [Content Brief]
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[2]. Stevens R, Corradini L, Doods H. Preclinical Evaluation of Human Somatostatin Receptor 4 (hSSTR4) Agonist CNTX-0290 for Mixed Pain Conditions. The Journal of Pain. 2019 Apr 1;20(4):S73.
Keywords
