2923008-66-4
2923008-66-4
Chemical Structure
GSK_WRN4
- CAS No.: 2923008-66-4
- Formula:C16H20N2O4S
- Molecular Weight:336.41
InChIKey: UUGZQYZJHNKGTI-GFCCVEGCSA-N
SMILES: O=C1NC(C2CCCCC2)=CC=C1C(N[C@@H]3C=CS(=O)(C3)=O)=O
Biological Activity: GSK_WRN4 is an orally active WRN helicase inhibitor (pIC50=7.6). GSK_WRN4 induces DNA damage markers (p21, p-γH2AX, p-KAP1). GSK_WRN4 selectively inhibits microsatellite-unstable tumor growth in vitro and in vivo by inducing DNA double-strand breaks, particularly at expanded TA repeats and regions of DNA damage[1].
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GSK_WRN4 | 98.85% | GSK_WRN4 is an orally active WRN helicase inhibitor (pIC50=7.6). GSK_WRN4 induces DNA damage markers (p21, p-γH2AX, p-KAP1). GSK_WRN4 selectively inhibits microsatellite-unstable tumor growth in vitro and in vivo by inducing DNA double-strand breaks, particularly at expanded TA repeats and regions of DNA damage. | ||||||||||||||||||||
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References
Keywords
