292606-90-7
Chemical Structure
AP21998
- CAS No.: 292606-90-7
- Formula:C43H59N3O10
- Molecular Weight:777.94
InChIKey: OPUOJOSCCOTGGA-PUPDPRJKSA-N
SMILES: O=C(N1[C@@H](CCCC1)C(O[C@@H](C2=CC(OCC(NCCCN(C)C)=O)=CC=C2)CCC3=CC(OC)=C(C=C3)OC)=O)[C@H](C4=CC(OC)=C(C(OC)=C4)OC)CC
Biological Activity: AP21998 is a Fv (mutant FKBP) domain-selective ligand that binds to a single FKBPv. AP21998 disrupts FKBP-mediated oligomerization, blocks the proliferation of transformed myeloid progenitors and facilitates their terminal myeloid differentiation. AP21998 disrupts aggregates of CAD-hM1 receptor fusion protein, allowing receptors to exit the ER and enter the plasma membrane. AP21998 can be used for cancer research[1][2][3].
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AP21998 | AP21998 is a Fv (mutant FKBP) domain-selective ligand that binds to a single FKBPv. AP21998 disrupts FKBP-mediated oligomerization, blocks the proliferation of transformed myeloid progenitors and facilitates their terminal myeloid differentiation. AP21998 disrupts aggregates of CAD-hM1 receptor fusion protein, allowing receptors to exit the ER and enter the plasma membrane. AP21998 can be used for cancer research. | |||||||||||||||||||||
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- [1]. Sawyer GW, et al. Determination of the rate of muscarinic M1 receptor plasma membrane delivery using a regulated secretion/aggregation system. J Pharmacol Toxicol Methods. 2006 May-Jun;53(3):219-33. [Content Brief]
- [2]. Lin CH, et al. Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis. Sci Rep. 2019 Mar 20;9(1):4915. [Content Brief]
- [3]. Song GJ, et al. Regulated dimerization of the thyrotropin-releasing hormone receptor affects receptor trafficking but not signaling. Mol Endocrinol. 2005 Nov;19(11):2859-70. [Content Brief]
Keywords
