2934813-27-9
2934813-27-9
Chemical Structure
Dinotefuran-d3
Synonym(s): MTI-446-d3
- CAS. Nr.: 2934813-27-9
- Formula:C7H11D3N4O3
- Molecular Weight:205.23
IUPAC Name: (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide
InChIKey: YKBZOVFACRVRJN-FIBGUPNXSA-N
SMILES: [2H]C([2H])([2H])N/C(N[N+]([O-])=O)=N\CC1CCOC1
Biological Activity: Dinotefuran-d3 is the deuterium labeled Dinotefuran[1]. Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors[2].
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Dinotefuran-d3 | Dinotefuran-d3 is the deuterium labeled Dinotefuran. Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors. | |||||||||||||||||||||
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Dinotefuran (Standard) | ≥98% | Dinotefuran (Standard) is the analytical standard of Dinotefuran. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Dinotefuran | 99.74% | Dinotefuran is an orally active and competitive inhibitor and insecticide targeting insect nicotinic acetylcholine receptors (nAChRs). Dinotefuran blocks neural signaling and induces neural dysfunction in insects. Dinotefuran binds to [3H]epibatidine in the neural cord membrane of American cockroach with an IC50 of 890 nM and to [3H]α-bungarotoxin with an IC50 of 36.1 μM. Dinotefuran exhibits knockdown activity (KD50=0.351 nmol/g) and lethal activity (LD50=0.173 nmol/g) against German cockroach. Dinotefuran is mainly used for agricultural pest control, such as field control of piercing-sucking and chewing insects (e.g., aphids, planthoppers), while its environmental toxicological effects (e.g., oxidative stress and reproductive neurotoxicity on earthworms) are also a research focus to assess ecological risks. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Liu T, et al. Biochemical and genetic toxicity of dinotefuran on earthworms (Eisenia fetida). Chemosphere. 2017 Jun;176:156-164. [Content Brief]
