2945197-77-1
2945197-77-1
Chemical Structure
TNF-α-IN-11
- CAS No.: 2945197-77-1
- Formula:C24H26N2O5
- Molecular Weight:422.47
InChIKey: BKTIPXAFPMVBOY-SFHVURJKSA-N
SMILES: O=C(N(CCC1=CC=C2C(OCO2)=C1)C(C3)=O)[C@H]3NC(C4=CC=C(C(C)(C)C)C=C4)=O
Biological Activity: TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor with a KD value of 12.06 μM. TNF-α-IN-11 binds to TNF-α and blocks the activation of TNF-α-trigged caspase and NF-κB signaling pathway. TNF-α-IN-11 inhibits the phosphorylation of IκBα, as well as the nuclear translocation of NF κB p65. TNF-α-IN-11 can be used for research of TNF-α-mediated autoimmune diseases[1].
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TNF-α-IN-11 | TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor with a KD value of 12.06 μM. TNF-α-IN-11 binds to TNF-α and blocks the activation of TNF-α-trigged caspase and NF-κB signaling pathway. TNF-α-IN-11 inhibits the phosphorylation of IκBα, as well as the nuclear translocation of NF κB p65. TNF-α-IN-11 can be used for research of TNF-α-mediated autoimmune diseases. | |||||||||||||||||||||
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