2965385-11-7
Chemical Structure
HPK1-IN-72
- CAS No.: 2965385-11-7
- Formula:C25H26N4O4S
- Molecular Weight:478.56
InChIKey: BYBPOOMGJIZMMY-UHFFFAOYSA-N
SMILES: OC(C)(C#CC1=CC(COC2=CC(C3=NC4=C(S3)CN(CC4)C(CO)=O)=CN=C2N)=CC=C1)C
Biological Activity: HPK1-IN-72 is an orally active and selective HPK1/MAP4K1 inhibitor with an IC50 of 52.4 nM against human targets. HPK1-IN-72 inhibits HPK1 activation, blocks the negative regulation of T cell receptor signaling, restores T cell receptor signal transduction and enhances T cell function. HPK1-IN-72 suppresses tumor growth, exhibits potent single-agent anti-tumor efficacy, and also produces synergistic effects with anti-PD-1 antibodies or anti-PD-L1/IL-15 immunocytokine prodrugs. HPK1-IN-72 can be used in research related to breast cancer, colorectal cancer and prostate cancer[1].
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HPK1-IN-72 | HPK1-IN-72 is an orally active and selective HPK1/MAP4K1 inhibitor with an IC50 of 52.4 nM against human targets. HPK1-IN-72 inhibits HPK1 activation, blocks the negative regulation of T cell receptor signaling, restores T cell receptor signal transduction and enhances T cell function. HPK1-IN-72 suppresses tumor growth, exhibits potent single-agent anti-tumor efficacy, and also produces synergistic effects with anti-PD-1 antibodies or anti-PD-L1/IL-15 immunocytokine prodrugs. HPK1-IN-72 can be used in research related to breast cancer, colorectal cancer and prostate cancer. | |||||||||||||||||||||
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