2969160-15-2
2969160-15-2
Chemical Structure
Monoamine Oxidase B inhibitor 5
- CAS No.: 2969160-15-2
- Formula:C16H14FN3O2
- Molecular Weight:299.30
InChIKey: AOGHVXHSPZUBKO-UHFFFAOYSA-N
SMILES: FC1=CC=C(COC2=CC=C(NC(CC(N)=O)=N3)C3=C2)C=C1
Biological Activity: Monoamine Oxidase B inhibitor 5 (Compound 16d) is a selective and reversible inhibitor for monoamine oxidase B (hMAO-B) with an IC50 of 67.3 nM and a Ki of 82.5 nM. Monoamine Oxidase B inhibitor 5 exhibits good pharmacokinetic characters and weak toxicity in rats model. Monoamine Oxidase B inhibitor 5 alleviates MPTP-induced (HY-15608) motor impairment in Parkinson’s mouse model. Monoamine Oxidase B inhibitor 5 is blood-brain barrier (BBB) penetrate[1].
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Monoamine Oxidase B inhibitor 5 | Monoamine Oxidase B inhibitor 5 (Compound 16d) is a selective and reversible inhibitor for monoamine oxidase B (hMAO-B) with an IC50 of 67.3 nM and a Ki of 82.5 nM. Monoamine Oxidase B inhibitor 5 exhibits good pharmacokinetic characters and weak toxicity in rats model. Monoamine Oxidase B inhibitor 5 alleviates MPTP-induced (HY-15608) motor impairment in Parkinson’s mouse model. Monoamine Oxidase B inhibitor 5 is blood-brain barrier (BBB) penetrate. | |||||||||||||||||||||
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