29826-16-2
Chemical Structure
Dihydronovobiocin
- CAS No.: 29826-16-2
- Formula:C31H38N2O11
- Molecular Weight:614.64
IUPAC Name: (3R,4S,5R,6R)-5-hydroxy-6-((4-hydroxy-3-(4-hydroxy-3-isopentylbenzamido)-8-methyl-2-oxo-2H-chromen-7-yl)oxy)-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate
InChIKey: JJYCENBZIMIWTM-KGSXXDOSSA-N
SMILES: CC1=C2C(C(O)=C(C(O2)=O)NC(C3=CC(CCC(C)C)=C(C=C3)O)=O)=CC=C1O[C@H]4[C@@H]([C@@H]([C@H](C(C)(O4)C)OC)OC(N)=O)O
Biological Activity: Dihydronovobiocin is a bacterial inhibitor and ATPase inhibitor that can bind to GyrB. Dihydronovobiocin can be used to study the interaction between coumarin antibiotics (such as Novobiocin, Chlorobiocin, and Coumermycin) and DNA gyrase. Dihydronovobiocin also has the potential to study bacterial infections[1][2].
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Dihydronovobiocin | Dihydronovobiocin is a bacterial inhibitor and ATPase inhibitor that can bind to GyrB. Dihydronovobiocin can be used to study the interaction between coumarin antibiotics (such as Novobiocin, Chlorobiocin, and Coumermycin) and DNA gyrase. Dihydronovobiocin also has the potential to study bacterial infections. | |||||||||||||||||||||
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- [1]. Gormley NA, et al. The interaction of coumarin antibiotics with fragments of DNA gyrase B protein. Biochemistry. 1996 Apr 16;35(15):5083-92. [Content Brief]
- [2]. Oram M, et al. Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase. Antimicrob Agents Chemother. 1996 Feb;40(2):473-6. [Content Brief]
Keywords
